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/ 161 FIGURE 8.5 Histology of acute MS plaques: A. perivascular lymphocytic infiltration. Disintegration of myelin in B. oilred-O-positive neutral lipid globules. Macrophages C. remove debris of myelin. Fibrous astrocytes D. produce fine fibrillar processes. AB AB CD Figure 8.6 Chronic plaques in September Dense gliosis and demyelination in subcortical plate. C. demyelination in the range tegmentum demyelinated and small foci in the base of the protuberance and D. dense astrogliosis in the demyelinated areas. CD 162 / Clinical Neuropathology: Text and Colour Atlas ABC Figure 8.7 Changes in nerve fibers within the plaques in September A. At the margin of a plate, the myelin sheaths are severely disrupted, but a reduced number of nerve fibers is spared. B. Moderate loss and total nerve fibers in the center of a plate column. FIGURE 8.8 oligodendrocytes in chronic MS plaques. Oligodendrocytes are rare A. among large fibrillary astrocytes. Plate B. depleted of oligodendrocytes. AB Figure 8.9 Preservation of neurons within the MS plaque. A shadow or remyelinating plaque shows reduced density of myelin, thin and lightly brown the myelin sheaths, and moderate to large numbers of oligodendrocytes.

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